However three baseline errors from Isner and an ace out wide from Sangren leveled the set at five games all as Sangren held serve at love.
Then serving at 30 all, Isner struck two consecutive aces out wide to hold serve and lead 6-5.
Serving in the following game to stay in the match at 0-30, Sangren sent an ace out wide to reach 15-30 before striking two overhead winners to hold serve and level the set at six games all.
With Isner at the net in the opening point of the final set tiebreaker, Sandgren netted a crosscourt forehand passing shot before framing a down the line forehand on the following point to trail 0-2.
Sangren then struck a crosscourt backhand passing shot wide to trail 1-3.
The six feet ten inches tall Isner then sent an ace down the tee; his 19th ace to zero double faults for the day, to lead 4-1.
Isner then ripped a massive inside out crosscourt forehand return winner to lead 5-1.
Rushing the net on the following point, Isner sent a down the line forehand half volley wide reach 5-2.
Sangren netted a forehand return to trail 2-6 and face matchpoint.
A final powerful crosscourt backhand winner from Isner would end the match; the first meeting between perhaps America’s hottest hotshots.
The 33 year old Isner, currently ranked 10th, reached the quarterfinals in September at the US Open after reaching the semifinals at Wimbledon.
The six feet two inches tall 27 year old Sangren finished as a quarterfinalist in January at the Australian Open in a surprise break out performance.
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